Balkan Endemic nephropathy and the causative role of aristolochic acid
| Autor: | Živka Dika, Marie Stiborová, Jean-Louis Vanherweghem, Jean-Marie Colet, Joëlle Nortier, Nikola Pavlović, Jovan Nikolic, Bojan Jelaković, Volker M. Arlt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Balkan Nephropathy aristolochic acid 030232 urology & nephrology Aristolochic acid Disease Malignancy Gastroenterology Nephropathy 03 medical and health sciences chemistry.chemical_compound DNA Adducts 0302 clinical medicine Internal medicine Balkan endemic nephropathy aristolochic acid nephropathy upper tract urothelial carcinoma aristolo chic acid Aristolochia species Renal fibrosis Medicine Animals Humans Mass Screening Carcinoma Transitional Cell biology Néphrologie - urologie business.industry Ureteral Neoplasms Outbreak Aristolochia clematitis Environmental Exposure Aristolochia biology.organism_classification medicine.disease Kidney Neoplasms 030104 developmental biology chemistry Nephrology Carcinogens Aristolochic Acids business Tubulointerstitial Disease |
| Zdroj: | Jelaković, B, Dika, Ž, Arlt, V M, Stiborova, M, Pavlović, N M, Nikolić, J, Colet, J-M, Vanherweghem, J-L & Nortier, J L 2019, ' Balkan Endemic nephropathy and the causative role of aristolochic acid ', Seminars in Nephrology, vol. 39, no. 3, pp. 284-296 . https://doi.org/10.1016/j.semnephrol.2019.02.007 Seminars in nephrology, 39 (3 |
| Popis: | Summary: Balkan endemic nephropathy is a chronic tubulointerstitial disease with insidious onset, slowly progressing to end-stage renal disease and frequently associated with urothelial carcinoma of the upper urinary tract (UTUC). It was described in South-East Europe at the Balkan peninsula in rural areas around tributaries of the Danube River. After decades of intensive investigation, the causative factor was identified as the environmental phytotoxin aristolochic acid (AA)contained in Aristolochia clematitis, a common plant growing in wheat fields that was ingested through home-baked bread. AA initially was involved in the outbreak of cases of rapidly progressive renal fibrosis reported in Belgium after intake of root extracts of Aristolochia fangchi imported from China. A high prevalence of UTUC was found in these patients. The common molecular link between Balkan and Belgian nephropathy cases was the detection of aristolactam-DNA adducts in renal tissue and UTUC. These adducts are not only biomarkers of prior exposure to AA, but they also trigger urothelial malignancy by inducing specific mutations (A:T to T:A transversion)in critical genes of carcinogenesis, including the tumor-suppressor TP53. Such mutational signatures are found in other cases worldwide, particularly in Taiwan, highlighting the general public health issue of AA exposure by traditional phytotherapies. SCOPUS: re.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|