Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study
| Autor: | Tung Ping Su, Bing Zhang, Shih-Jen Tsai, Ya Mei Bai, Tzeng Ji Chen, Yen-Po Wang, Hohui E. Wang, Mu Hong Chen |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Longitudinal study Databases Factual Population Taiwan Disease Inflammatory bowel disease 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine mental disorders medicine Humans Dementia Longitudinal Studies education Aged Aged 80 and over education.field_of_study business.industry Incidence Incidence (epidemiology) Age Factors Gastroenterology Middle Aged Inflammatory Bowel Diseases medicine.disease Ulcerative colitis digestive system diseases Case-Control Studies Female 030211 gastroenterology & hepatology business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Gut. 70:85-91 |
| ISSN: | 1468-3288 0017-5749 |
| DOI: | 10.1136/gutjnl-2020-320789 |
| Popis: | ObjectiveIncreasing evidence supports reciprocal communication between the enteric and the central nervous system in disease, termed the ‘gut–brain axis’. Recent findings suggest a connection between IBD and development of Parkinson’s disease. The role of IBD in dementia, another insidious neurodegenerative disorder, has not been explored.DesignUsing the Taiwanese National Health Insurance Research Database, we performed comparative analysis of 1742 patients with IBD ≥45 years old against 17 420 controls to assess dementia risk following IBD diagnosis. Controls were matched on bases of sex, access to healthcare, income and dementia-related comorbidities. All individuals were followed for dementia diagnosis for up to 16 years. Subanalyses included the relationship between sex, ulcerative colitis (UC) and Crohn’s disease (CD), and dementia risk.ResultsOverall incidence of dementia among patients with IBD was significantly elevated (5.5% vs 1.4% among controls). Patients with IBD were diagnosed with dementia at 76.24 years old on average, compared with 83.45 among controls. The HR of developing dementia among patients with IBD was 2.54 (95% CI 1.91 to 3.37). Among dementia types, the risk of developing Alzheimer’s dementia demonstrated the greatest increase. Dementia risk did not differ between sex differences nor UC versus CD.ConclusionThis population-based cohort study demonstrates significant association between IBD and subsequent development of dementia. Dementia was diagnosed at an earlier age among patients with IBD, and disease risk appeared to increase with IBD chronicity. These findings highlight the need for future research to elucidate the relationship between IBD and dementia. |
| Databáze: | OpenAIRE |
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