Prognostic significance of margin clearance in pancreaticoduodenectomy specimens with pancreatic ductal adenocarcinoma in a Danish population-based nationwide study
| Autor: | Trine Aaquist, Claus W. Fristrup, Jane P. Hasselby, Stephen Hamilton-Dutoit, Mikkel Eld, Per Pfeiffer, Michael B. Mortensen, Sönke Detlefsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Aaquist, T, Fristrup, C W, Hasselby, J P, Hamilton-Dutoit, S, Eld, M, Pfeiffer, P, Mortensen, M B & Detlefsen, S 2023, ' Prognostic significance of margin clearance in pancreaticoduodenectomy specimens with pancreatic ductal adenocarcinoma in a Danish population-based nationwide study ', H P B . https://doi.org/10.1016/j.hpb.2023.03.016 Aaquist, T, Fristrup, C W, Hasselby, J P, Hamilton-Dutoit, S, Eld, M, Pfeiffer, P, Mortensen, M B & Detlefsen, S 2023, ' Prognostic significance of margin clearance in pancreaticoduodenectomy specimens with pancreatic ductal adenocarcinoma in a Danish population-based nationwide study ', H P B, vol. 25, no. 7, pp. 826-835 . https://doi.org/10.1016/j.hpb.2023.03.016 Aaquist, T, Fristrup, C W, Hasselby, J P, Hamilton-Dutoit, S, Eld, M, Pfeiffer, P, Mortensen, M B & Detlefsen, S 2023, ' Prognostic significance of margin clearance in pancreaticoduodenectomy specimens with pancreatic ductal adenocarcinoma in a Danish population-based nationwide study ', HPB, vol. 25, no. 7, pp. 826-835 . https://doi.org/10.1016/j.hpb.2023.03.016 |
| DOI: | 10.1016/j.hpb.2023.03.016 |
| Popis: | BackgroundIn this nationwide population-based cohort study, we investigated the overall minimum margin width that is independently associated with improved survival following pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC) and evaluated whether certain margins or surfaces hold independent prognostic significance.MethodsData from 367 patients who underwent PD for PDAC in the period 2015–2019 were retrieved from the Danish Pancreatic Cancer Database. Missing data were obtained by review of pathology reports and re-microscopy of resection specimens. Surgical specimens were evaluated using a standardised pathological protocol involving multicolour inking, axial slicing and exact reporting of circumferential margin clearances in 0.5 mm increments.ResultsWhen categorised according to margin widths of ConclusionMargin clearance of at least 1.5 mm was independently associated with improved survival following PD for PDAC. BackgroundIn this nationwide population-based cohort study, we investigated the overall minimum margin width that is independently associated with improved survival following pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC) and evaluated whether certain margins or surfaces hold independent prognostic significance.MethodsData from 367 patients who underwent PD for PDAC in the period 2015–2019 were retrieved from the Danish Pancreatic Cancer Database. Missing data were obtained by review of pathology reports and re-microscopy of resection specimens. Surgical specimens were evaluated using a standardised pathological protocol involving multicolour inking, axial slicing and exact reporting of circumferential margin clearances in 0.5 mm increments.ResultsWhen categorised according to margin widths of ConclusionMargin clearance of at least 1.5 mm was independently associated with improved survival following PD for PDAC. |
| Databáze: | OpenAIRE |
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