Nosocomial outbreak of Aspergillus fumigatus infection among patients in a renal unit?
| Autor: | Giordano F, M. Meroni, P. Casella, F. Pitingolo, Adalberto Sessa, M. Marks, Graziana Battini |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Opportunistic Infections Aspergillosis Aspergillus fumigatus Disease Outbreaks Fatal Outcome Internal medicine medicine Environmental Microbiology Humans Hospital Design and Construction Mycosis Aged Aged 80 and over Transplantation Aspergillus Cross Infection Lung biology Lung Diseases Fungal business.industry Granulomatosis with Polyangiitis Immunosuppression Middle Aged biology.organism_classification medicine.disease Surgery medicine.anatomical_structure Italy Nephrology Kidney Failure Chronic Female Hemodialysis Allergic bronchopulmonary aspergillosis business |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 11(7) |
| ISSN: | 0931-0509 |
| Popis: | Aspergillus fumigatus is present in the environment worldwide and it is only able to infect debilitated or immunodepressed subjects. Nosocomial outbreaks of A. fumigatus infection have been associated with hospital reconstruction. Spores are released into the environment and are inhaled by immunodepressed patients housed in nearby Medical Units. Specific clinical syndromes are allergic bronchopulmonary aspergillosis and invasive pulmonary aspergillosis with characteristic radiological features. Invasive A. fumigatus infection is commonly fatal, even if promptly diagnosed and treated. Three consecutive cases of A. fumigatus infection occurred in debilitated patients housed in our Renal Unit while building renovation near the Unit was being performed. Two of these patients died and pulmonary and diffuse aspergillosis was found on postmortem examination. The third patient, highly suspected to be infected with Aspergillus, was aggressively and successfully treated with liposomal amphotericin B. Our experience suggests that fungal infections have gained increasing prominence in clinical medicine and they must be considered in chronic debilitated patients including dialysis patients, and that liposomal amphotericin B represents an important advance in the treatment of aspergillosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|