Port-site metastases following laparoscopic surgery

Autor: David I. Watson, P. J. Hewett, Susan J. Neuhaus, M. Texler
Rok vydání: 1998
Předmět:
Zdroj: British Journal of Surgery. 85:735-741
ISSN: 1365-2168
0007-1323
DOI: 10.1046/j.1365-2168.1998.00769.x
Popis: Background Application of laparoscopy to the resection of malignancy has been followed by a literature describing cases of metastatic involvement at laparoscopic port sites. These include patients who underwent surgery for early stage carcinoma and instances following laparoscopic procedures during which tumours were not dissected. Methods Recently published clinical and experimental studies, and case reports related to this problem are reviewed; their relevance is discussed. Results Experimental studies incorporating bench top and large animal models have confirmed that tumour cells may be redistributed to port sites during laparoscopic surgery either directly from contaminated instruments or indirectly via the insufflation gas. Small animal models suggest that the incidence of wound metastasis is increased following conventional laparoscopic surgery, and that it may be decreased by gasless laparoscopy or helium insufflation. This evidence suggests that the development of port-site metastases depends not only on the physical redistribution of tumour cells but also on the specific insufflation gas used, possibly because of influences on local metabolic or immune factors acting at the wound site. Conclusion Further research in this area is urgent. Until the issue is better understood, patients undergoing laparoscopic surgery for malignancy should be entered into clinical trials.
Databáze: OpenAIRE
Externí odkaz: