Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease
| Autor: | Qin Nie, Xiao-guang Du, Meiyu Geng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
Amyloid beta-Peptides Amyloid Chemistry Aβ peptide P3 peptide General Medicine Disease Review medicine.disease Combinatorial chemistry Small molecule Amyloid β peptide Drug Delivery Systems Alzheimer Disease Drug Design medicine Animals Humans Pharmacology (medical) Alzheimer's disease Neuroscience Therapeutic strategy |
| Popis: | Amyloid β (Aβ) peptides have long been viewed as a potential target for Alzheimer's disease (AD). Aggregation of Aβ peptides in the brain tissue is believed to be an exclusively pathological process. Therefore, blocking the initial stages of Aβ peptide aggregation with small molecules could hold considerable promise as the starting point for the development of new therapies for AD. Recent rapid progresses in our understanding of toxic amyloid assembly provide a fresh impetus for this interesting approach. Here, we discuss the problems, challenges and new concepts in targeting Aβ peptides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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