Effect of high-velocity and traditional resistance exercise on serum antioxidants and inflammation biomarkers in older women: A randomized crossover trial
| Autor: | Dahan da Cunha Nascimento, Ivo Vieira de Sousa Neto, Fabiani Lage Rodrigues Beal, Thiago Santos Rosa, Vânia Silva Macedo Orsano, Jonato Prestes, Danilo Leandro Santos de Castro, Whitley J. Stone |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Senescence Aging Antioxidant medicine.medical_treatment Population Physiology Inflammation medicine.disease_cause Biochemistry Antioxidants Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Genetics Humans Medicine education Molecular Biology Aged education.field_of_study Cross-Over Studies biology business.industry Resistance Training Cell Biology Glutathione Crossover study Oxidative Stress 030104 developmental biology chemistry biology.protein Female medicine.symptom business Biomarkers 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Experimental Gerontology. 139:111026 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2020.111026 |
| Popis: | Introduction Contrary to the production of oxidant and inflammation biomarkers, antioxidant enzymes decrease with age and the adaptive response to oxidative stress is reduced. The effects of the different resistance exercise protocols to attenuate these conditions are largely unexplored. Objective We compared the acute effects of traditional resistance exercise (TRE) and high velocity RE (HVRE) on inflammatory biomarkers and antioxidant activity in elderly women. Methods Fourteen elderly women (67 ± 7 years) were randomly assigned to TRE or HVRE. Blood samples were collected to measure inflammatory markers and antioxidant enzymes at three time-points (pre-exercise, post-exercise, 30 min post-exercise). Results TRE and HVRE induced acute reductions over time on tumor necrosis factor-alpha, interleukin-6 (IL-6), soluble receptor of IL-6 (sIL-6R), as well in catalase, glutathione and superoxide dismutase antioxidant levels without differences between groups. In addition, TRE and HVRE groups displayed acute increments in interleukin-10 (IL-10) and IL-10/IL-6 ratio over time, while the HVRE protocol displayed higher IL-10 values post-exercise and 30 min post-exercise time points as compared with TRE. Based on magnitude based inference, subjects from the HVRE group demonstrated superior responsiveness for IL-6 and IL-10 as compared with the TRE group. All participants from the HVRE group displayed a minimal clinical important difference on IL-10 levels as compared to only two persons from the TRE group. Conclusion Both RE protocols were capable of positive changes in inflammatory and antioxidant status in elderly subjects, but HVRE demonstrated a superior response on IL-10. The HVRE may be incorporated to exercise recommendation in this population. |
| Databáze: | OpenAIRE |
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