Adult Granulosa Cell Tumor: A Sinister Differential for Clomiphene-resistant Infertility
| Autor: | Shalini Gainder, Japleen Kaur, Nalini Gupta, Sujata Siwatch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Infertility medicine.medical_specialty medicine.drug_class Granulosa cell medicine.medical_treatment Ovary Case Report Hyperestrogenism lcsh:Gynecology and obstetrics Clomiphene 03 medical and health sciences 0302 clinical medicine Vascularity granulosa cell tumor follow-up Medicine Laparoscopy lcsh:RG1-991 Gynecology medicine.diagnostic_test business.industry medicine.disease Androgen 030104 developmental biology medicine.anatomical_structure Reproductive Medicine 030220 oncology & carcinogenesis Ovulation induction medicine.symptom business infertility |
| Zdroj: | Journal of Human Reproductive Sciences Journal of Human Reproductive Sciences, Vol 11, Iss 2, Pp 190-192 (2018) |
| ISSN: | 1998-4766 0974-1208 |
| Popis: | Granulosa cell tumors (GCTs) are rare sex cord–stromal tumors of the ovary. They may present with features of hyperestrogenism. We present a case of a 29-year-old nulliparous female, with infertility and oligomenorrhoea, initially managed with a provisional diagnosis of polycystic ovarian syndrome. She did not respond to multiple cycles of ovulation induction with clomiphene citrate. Later, an ovarian mass was detected, and she was initially planned for laparoscopy. Magnetic resonance imaging pelvis revealed a solid-looking mass in the ovary, with increased vascularity. Fine-needle aspiration cytology from the mass suggested GCT. She underwent staging laparotomy with fertility-preserving surgery. Thereafter, she conceived on first cycle of clomiphene citrate. She delivered twins and is presently 8 months postpartum. Thus, a high index of suspicion for underlying androgen- or estrogen-secreting tumor in cases of clomiphene-resistant infertility with ovarian cysts is advisable. |
| Databáze: | OpenAIRE |
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