Toxic megacolon associated with Clostridium difficile infection recurrence: a case report complicated by multiple bacterial infections and successfully treated with oral fidaxomicin
| Autor: | Giuseppina Dell'Aquila, Patrizia Maio, Nicola Acone, Mario Magliocca, Sergio Giglio, Addolorata Masiello |
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| Přispěvatelé: | This supplement is funded and supported by Astellas Pharma S.p.A. |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Toxic megacolon
medicine.medical_specialty medicine.drug_class Antibiotics Medicine (miscellaneous) Gastroenterology Clostridium difficile Fidaxomicin Refractory Internal medicine medicine Colitis lcsh:R5-920 business.industry medicine.disease Surgery Metronidazole Business Management and Accounting (miscellaneous) Vancomycin Infectivology lcsh:Medicine (General) business medicine.drug |
| Zdroj: | Clinical Management Issues; Vol 8, No 1S (2014); 17-20 Clinical Management Issues, Vol 8, Iss 1S, Pp 17-20 (2014) |
| ISSN: | 1973-4832 2283-3137 |
| Popis: | Toxic megacolon is a severe complication of Clostridium difficile infection (CDI) with a high percentage of mortality. The mainstay of treatment is currently represented by medical management, while surgical intervention is indicated in patients not improving after 2-3 days of antibiotic therapy. Generally metronidazole and vancomycin are administered as first-line treatment, but recently several cases of refractory C. difficile have made the treatment of this infection more difficult. Fidaxomicin is a narrow-spectrum oral macrocyclic antibiotic with excellent in vitro activity against C. difficile strains. We report the case of a woman admitted with a diagnosis of toxic megacolon complicating a C. difficile colitis not responding to standard antibiotic therapy. |
| Databáze: | OpenAIRE |
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