Enantioseparation through Supercritical Fluid Simulated Moving Bed (SF-SMB) Chromatography
| Autor: | Massimo Morbidelli, Roger Marc Nicoud, Jean-Noël Jaubert, Orazio Di Giovanni and, and Willy Hauck, Marco Mazzotti, Félicie Denet |
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| Přispěvatelé: | Institute of Process Engineering, Laboratoire de Thermodynamique des séparations (LTS), Institut National Polytechnique de Lorraine (INPL) |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Work (thermodynamics)
Chromatography General Chemical Engineering 010401 analytical chemistry Analytical chemistry 02 engineering and technology General Chemistry 021001 nanoscience & nanotechnology 01 natural sciences Industrial and Manufacturing Engineering Supercritical fluid 0104 chemical sciences chemistry.chemical_compound chemistry [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering Triangle theory Simulated moving bed 0210 nano-technology Pressure gradient ComputingMilieux_MISCELLANEOUS |
| Zdroj: | Industrial and engineering chemistry research Industrial and engineering chemistry research, American Chemical Society, 2001, 40 (21), pp.4603-4609. ⟨10.1021/ie000959v⟩ |
| ISSN: | 0888-5885 1520-5045 |
| DOI: | 10.1021/ie000959v⟩ |
| Popis: | In this work, the first enantioseparation in a SF-SMB unit, i.e., a simulated moving bed (SMB) operated under supercritical conditions, is reported. Complete separation of the two enantiomers of tetralol was achieved both in the pressure-gradient mode (where a pressure gradient is imposed along the four sections of the unit) and in the isocratic mode (where the pressure is kept constant). However, an almost 3-fold increase in productivity could be achieved in the pressure-gradient rather than the isocratic mode. The obtained results are explained and rationalized using recently developed design criteria for SMBs, the so-called “triangle theory”, which have been properly extended to allow for different pressure values in the different sections of the unit. |
| Databáze: | OpenAIRE |
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