Left Frontal Hub Connectivity during Memory Performance Supports Reserve in Aging and Mild Cognitive Impairment
| Autor: | Alexander N.W. Taylor, Robert Stahl, Katharina Buerger, Miguel Ángel Araque Caballero, Michael Ewers, Martin Dichgans, Lana Kambeitz-Ilankovic, Julia Hartmann, Daniel Janowitz, Lee Simon-Vermot, Birgit Ertl-Wagner, Claudia Mueller, Marco Duering, Nicolai Franzmeier, Cihan Catak |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Aging pathology [Cognitive Dysfunction] Neural substrate diagnostic imaging [Cognitive Dysfunction] pathology [Nerve Net] Hippocampus pathology [Frontal Lobe] Audiology Brain mapping Functional Laterality memory pathology [Aging] 0302 clinical medicine Neural Pathways Image Processing Computer-Assisted Names Cognitive reserve Aged 80 and over education Brain Mapping General Neuroscience Psychophysiological Interaction physiology [Pattern Recognition Visual] Cognition General Medicine cognitive reserve Magnetic Resonance Imaging diagnostic imaging [Neural Pathways] Frontal Lobe Psychiatry and Mental health Clinical Psychology Pattern Recognition Visual Frontal lobe Female Research Article Cognitive psychology medicine.medical_specialty task-fMRI 03 medical and health sciences mild cognitive impairment Apolipoproteins E Sex Factors Atrophy diagnostic imaging [Frontal Lobe] medicine Humans Cognitive Dysfunction ddc:610 physiology [Memory] Aged diagnostic imaging [Nerve Net] business.industry functional connectivity genetics [Cognitive Dysfunction] physiology [Functional Laterality] medicine.disease 030104 developmental biology Face genetics [Apolipoproteins E] Nerve Net Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease Journal of Alzheimer's disease 59(4), 1381-1392 (2017). doi:10.3233/JAD-170360 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-170360 |
| Popis: | Reserve in aging and Alzheimer's disease (AD) is defined as maintaining cognition at a relatively high level in the presence of neurodegeneration, an ability often associated with higher education among other life factors. Recent evidence suggests that higher resting-state functional connectivity within the frontoparietal control network, specifically the left frontal cortex (LFC) hub, contributes to higher reserve. Following up these previous resting-state fMRI findings, we probed memory-task related functional connectivity of the LFC hub as a neural substrate of reserve. In elderly controls (CN, n = 37) and patients with mild cognitive impairment (MCI, n = 17), we assessed global connectivity of the LFC hub during successful face-name association learning, using generalized psychophysiological interaction analyses. Reserve was quantified as residualized memory performance, accounted for gender and proxies of neurodegeneration (age, hippocampus atrophy, and APOE genotype). We found that greater education was associated with higher LFC-connectivity in both CN and MCI during successful memory. Furthermore, higher LFC-connectivity predicted higher residualized memory (i.e., reserve). These results suggest that higher LFC-connectivity contributes to reserve in both healthy and pathological aging. |
| Databáze: | OpenAIRE |
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