Double-Layer Mediated Electromechanical Response of Amyloid Fibrils in Liquid Environment
| Autor: | Sergei V. Kalinin, Maxim Nikiforov, Alexey Vertegel, Stephen Jesse, Senli Guo, Gary L. Thompson, Vladimir Reukov, Brian J. Rodriguez, Katyayani Seal |
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| Rok vydání: | 2010 |
| Předmět: |
Amyloid
Materials science Mechanical Phenomena General Physics and Astronomy Nanotechnology Article Electricity Microscopy Animals General Materials Science Protein Structure Quaternary Double layer (biology) chemistry.chemical_classification Biomolecule General Engineering Water Piezoelectricity Shear (sheet metal) Piezoresponse force microscopy chemistry Multivariate Analysis Aluminum Silicates Cattle Protein Multimerization Excitation |
| Zdroj: | ACS Nano. 4:689-698 |
| ISSN: | 1936-086X 1936-0851 |
| Popis: | Harnessing electrical bias-induced mechanical motion on the nanometer and molecular scale is a critical step towards understanding the fundamental mechanisms of redox processes and implementation of molecular electromechanical machines. Probing these phenomena in biomolecular systems requires electromechanical measurements be performed in liquid environments. Here we demonstrate the use of band excitation piezoresponse force microscopy for probing electromechanical coupling in amyloid fibrils. The approaches for separating the elastic and electromechanical contributions based on functional fits and multivariate statistical analysis are presented. We demonstrate that in the bulk of the fibril the electromechanical response is dominated by double-layer effects (consistent with shear piezoelectricity of biomolecules), while a number of electromechanically active hot spots possibly related to structural defects are observed. |
| Databáze: | OpenAIRE |
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