The concentration of plasma atrial natriuretic peptide in normotensive and preeclamptic pregnancies
| Autor: | N. Sahin, Oya Gökmen, T. Özcan, Selim Şenöz, B. Direm |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Blood Pressure Peptide hormone Preeclampsia Atrial natriuretic peptide Pre-Eclampsia Pregnancy Reference Values Internal medicine Hypovolemia medicine Humans reproductive and urinary physiology Analysis of Variance business.industry Case-control study Obstetrics and Gynecology medicine.disease Endocrinology Blood pressure Reproductive Medicine Evaluation Studies as Topic Case-Control Studies Gestation Female medicine.symptom business Atrial Natriuretic Factor |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 62(2) |
| ISSN: | 0301-2115 |
| Popis: | Atrial natriuretic peptide (ANP) is a family of peptides secreted by the heart, affecting the cardiovascular, renal and endocrine systems. This study questions previous research findings regarding elevated ANP levels, despite vasoconstriction and hypovolemia, in preeclamptic patients. Materials and methods: Seventeen patients with preeclampsia, 5 with superimposed preeclampsia with chronic hypertension and 17 normotensive pregnant women were compared with respect to plasma ANP levels. Seventeen non-pregnant women were taken as the control group. All the women, except the ones with superimposed preeclampsia, were age matched and in their third trimester. Results: ANP levels in the non-pregnant women (6.9 ± 0.7 pg/ml) were not different from those in the normotensive pregnant women (6.4 ± 0.7 pg/ml). ANP levels were significantly higher in women with preeclampsia (10.8 ± 1.8 pg/ml) or superimposed preeclampsia (9.7 ± 1.4 pg/ml) than in normotensive pregnant women and normal non-pregnant women (P < 0.05). According to the literature, there is a volume depletion in preeclamptic women. However, this wasn't demonstrated in our study group. Conclusion: ANP levels in preeclamptic women were found to be higher than those in normotensive pregnant women. The etiology still remains obscure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect