Efficient Fragment Coupling Approaches toward Large Oxacalix[n]arenes (n = 6, 8)

Autor:	Wim Van Rossom, Margriet Ovaere, Wouter Maes, Wim Dehaen, Luc Van Meervelt
Rok vydání:	2009
Předmět:	Coupling Fragment (logic) Stereochemistry Nucleophilic aromatic substitution Chemistry Organic Chemistry Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic Letters. 11:1681-1684
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol900116h
Popis:	The first rational, stepwise synthesis of enlarged oxacalix[n]arenes (n > 4) is described. Variously substituted oxacalix[3]arene[3]pyrimidines were prepared rather selectively by a straightforward [3 + 3] fragment coupling approach after a thorough search for the optimum nucleophilic aromatic substitution conditions. Similar procedures also allowed facile synthesis of unsymmetrical oxacalix[4]- and oxacalix[8]arenes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6ceb7acf5bd80f9e084f751c44cb50 https://doi.org/10.1021/ol900116h Zobrazit plný text záznamu