Human cutaneous B cells: what do we really know?
| Autor: | Christopher T. Richardson, Drew C Mitchell, Irina Lerman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Lupus erythematosus Systemic lupus erythematosus integumentary system business.industry T cell Antigen presentation Pemphigus vulgaris Human skin General Medicine medicine.disease 030207 dermatology & venereal diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Immune system Immunology medicine Review Article on Rheumatologic Skin Disease business B cell |
| Zdroj: | Ann Transl Med |
| ISSN: | 2305-5839 |
| Popis: | B cells play many critical roles in the systemic immune response, including antibody secretion, antigen presentation, T cell co-stimulation, and pro- and anti-inflammatory cytokine production. However, the contribution of B cells to the local immune response in many non-lymphoid tissues, such as the skin, is incompletely understood. Cutaneous B cells are scarce except in certain malignant and inflammatory conditions, and as such, have been poorly characterized until recently. Emerging evidence now suggests an important role for cutaneous B in both skin homeostasis and pathogenesis of skin disease. Herein, we discuss the potential mechanisms for cutaneous B cell recruitment, localized antibody production, and T cell interaction in human skin infections and primary skin malignancies (i.e., melanoma, squamous cell carcinoma). We further consider the likely contribution of cutaneous B cells to the pathogenesis of inflammatory skin diseases, including pemphigus vulgaris, lupus erythematosus, systemic sclerosis, hidradenitis suppurativa, and atopic dermatitis. Finally, we examine the feasibility of B cell targeted therapy in the dermatologic setting, emphasizing areas that are still open to investigation. Through this review, we hope to highlight what we really know about cutaneous B cells in human skin, which can sometimes be lost in reviews that more broadly incorporate extensive data from animal models. |
| Databáze: | OpenAIRE |
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