High Risk of Metabolic and Adipose Tissue Dysfunctions in Adult Male Progeny, Due to Prenatal and Adulthood Malnutrition Induced by Fructose Rich Diet

Autor: Guillermina Zubiría, Andrés Giovambattista, Gricelda Moreno, Ana Alzamendi, Eduardo Spinedi, Andrea Estefanía Portales
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Blood Glucose
Leptin
Male
Desnutrición
Adipose tissue
Weight Gain
Impaired glucose tolerance
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Adipocyte
insulin resistance
Tejido Adiposo
PROGRAMACION METABOLICA
Adiposity
Nutrition and Dietetics
Age Factors
purl.org/becyt/ford/3.1 [https]
Stromal vascular fraction
dysfunctional adipose tissue
Medicina Básica
Phenotype
Adipose Tissue
Prenatal Exposure Delayed Effects
adipocyte precursor cells
purl.org/becyt/ford/3 [https]
Animal Nutritional Physiological Phenomena
Female
altered glucose tolerance
lcsh:Nutrition. Foods and food supply
medicine.medical_specialty
metabolic programming
pre-diabetes
metabolic syndrome
CIENCIAS MÉDICAS Y DE LA SALUD
Offspring
Inmunología
lcsh:TX341-641
030209 endocrinology & metabolism
Fructose
Biology
Article
03 medical and health sciences
Insulin resistance
Sex Factors
Biología Celular
Microbiología
Internal medicine
medicine
Dietary Carbohydrates
Animals
Hypertriglyceridemia
Malnutrition
Maternal Nutritional Physiological Phenomena
medicine.disease
ADIPOGENESIS
030104 developmental biology
Endocrinology
chemistry
DIETA RICA EN FRUCTOSA
TEJIDO ADIPOSO BLANCO
Ciencias Médicas
Energy Intake
Biomarkers
Food Science
Zdroj: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Nutrients; Volume 8; Issue 3; Pages: 178
CIC Digital (CICBA)
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron:CICBA
Nutrients
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Nutrients, Vol 8, Iss 3, p 178 (2016)
Popis: The aim of this work was to determine the effect of a fructose rich diet (FRD) consumed by the pregnant mother on the endocrine-metabolic and in vivo and in vitro adipose tissue (AT) functions of the male offspring in adulthood. At 60 days of age, rats born to FRD-fed mothers (F) showed impaired glucose tolerance after glucose overload and high circulating levels of leptin (LEP). Despite the diminished mass of retroperitoneal AT, this tissue was characterized by enhanced LEP gene expression, and hypertrophic adipocytes secreting in vitro larger amounts of LEP. Analyses of stromal vascular fraction composition by flow cytometry revealed a reduced number of adipocyte precursor cells. Additionally, 60 day-old control (C) and F male rats were subjected to control diet (CC and FC animals) or FRD (CF and FF rats) for three weeks. FF animals were heavier and consumed more calories. Their metabolic-endocrine parameters were aggravated; they developed severe hyperglycemia, hypertriglyceridemia, hyperleptinemia and augmented AT mass with hypertrophic adipocytes. Our study highlights that manipulation of maternal diet induced an offspring phenotype mainly imprinted with a severely unhealthy adipogenic process with undesirable endocrine-metabolic consequences, putting them at high risk for developing a diabetic state.
Facultad de Ciencias Médicas
Databáze: OpenAIRE
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