Cytogenetic and immunological changes after dermal exposure to polycyclic aromatic hydrocarbons and UV radiation
| Autor: | Borská, L., Zdenek Fiala, Krejsek, J., Hamáková, K., Andrýs, C., Šmejkalová, J., Vokurková, D., Kremláček, J. |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Chromosome Aberrations Male Physiology Transferrin General Medicine Immunoglobulin E Administration Cutaneous Severity of Illness Index Treatment Outcome Immunoglobulin M Immune System Humans Psoriasis Female Ultraviolet Therapy alpha-Macroglobulins Lymphocytes Polycyclic Aromatic Hydrocarbons beta 2-Microglobulin Coal Tar Skin |
| Zdroj: | ResearcherID Scopus-Elsevier Europe PubMed Central |
| ISSN: | 0862-8408 |
| Popis: | Goeckerman's therapy (GT), which combines exposure to coal tar (polycyclic aromatic hydrocarbons - PAHs) and UV radiation (UV) is often used as the first option for treatment of psoriasis. However, PAHs and UV represent mutagenic, carcinogenic and immunotoxic agents. Therefore GT can represent a health risk for the patients. The group under observation consisted of thirty patients undergoing GT. Before and after the treatment, blood samples were collected and chromosomal aberrations and selected immunological markers were determined. The relationships between chromosomal aberrations and immunological markers and the extent (duration) of exposure to GT were evaluated. The Psoriasis Area and Severity Index (PASI) score confirmed the high efficacy of GT. However, significantly elevated levels of chromosomal aberrations of peripheral lymphocytes were also found after the therapy (p |
| Databáze: | OpenAIRE |
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