Photostable fluorescent probes based on multifunctional group substituted naphthalimide dyes for imaging of lipid droplets in live cells

Autor:	Xinwei Li, Jiqing Bian, Mingyang Fu, Yan Zhang, Hongmei Liu, Baoxiang Gao
Rok vydání:	2022
Předmět:	Diagnostic Imaging Naphthalimides General Chemical Engineering technology industry and agriculture General Engineering Humans Lipid Droplets equipment and supplies Fluorescent Dyes HeLa Cells Analytical Chemistry
Zdroj:	Analytical Methods. 14:1279-1284
ISSN:	1759-9679 1759-9660
DOI:	10.1039/d2ay00104g
Popis:	We designed and synthesized multifunctional group substituted naphthalimide (MFGNI) dyes by introducing glycine ethyl ester and azetidine on 1,8-naphthalimide. With different azetidine substituents, the emission of the MFGNI dyes was shifted from blue to green. These MFGNI dyes exhibited high photoluminescence quantum yields (61% to 85%) and large Stokes shifts (67 nm). The amides and hydroxyl groups improved the photostability of the MFGNI dyes. Due to the small molecular weight and lipophilic properties, these MFGNI dyes specifically stained lipid droplets in living cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc646fd1b926b2e7349e102e90037949 https://doi.org/10.1039/d2ay00104g Zobrazit plný text záznamu