Amaryllidaceae Alkaloids Belonging to Different Structural Subgroups Display Activity against Apoptosis-Resistant Cancer Cells
| Autor: | Antonio Evidente, Alessio Cimmino, Benjamin Lallemand, Alexander Kornienko, Anna Andolfi, Robert Kiss, Florence Lefranc, Thierry Gras, Delphine Lamoral-Theys, Jacques Dubois, Amina Abou-Donia, Gwendoline Van Goietsenoven, Véronique Mathieu |
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| Přispěvatelé: | G., Van Goietsenoven, Andolfi, Anna, B., Lallemand, Cimmino, Alessio, D., Lamoral They, T., Gra, A., Abou Donia, J., Duboi, F., Lefranc, V., Mathieu, A., Kornienko, R., Ki, Evidente, Antonio |
| Rok vydání: | 2010 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Apoptosis Biology Analytical Chemistry chemistry.chemical_compound Drug Discovery Humans Cytotoxic T cell Amaryllidaceae Alkaloids Cytotoxicity Pharmacology Molecular Structure Alkaloid Organic Chemistry Biological activity Lycorine Antineoplastic Agents Phytogenic Phenanthridines Complementary and alternative medicine chemistry Drug Resistance Neoplasm Cancer cell Cancer research Molecular Medicine Drug Screening Assays Antitumor |
| Zdroj: | Journal of Natural Products. 73:1223-1227 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np9008255 |
| Popis: | Fifteen Amaryllidaceae alkaloids (1-15) were evaluated for their antiproliferative activities against six distinct cancer cell lines. Several of these natural products were found to have low micromolar antiproliferative potencies. The log P values of these compounds did not influence their observed activity. When active, the compounds displayed cytostatic, not cytotoxic activity, with the exception of pseudolycorine (3), which exhibited cytotoxic profiles. The active compounds showed similar efficacies toward cancer cells irrespective of whether the cell lines were responsive or resistant to proapoptotic stimuli. Altogether, the data from the present study revealed that lycorine (1), amarbellisine (6), haemanthamine (14), and haemanthidine (15) are potentially useful chemical scaffolds to generate further compounds to combat cancers associated with poor prognoses, especially those naturally resistant to apoptosis, such as glioblastoma, melanoma, non-small-cell lung, and metastatic cancers. |
| Databáze: | OpenAIRE |
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