Presence of S-100β in cholinergic neurones of the rat hindbrain
| Autor: | Nastaran Khatibi, Anders Hamberger, Torgny Stigbrand, Qiner Yang, Kenneth G. Haglid |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Central nervous system Biology Choline O-Acetyltransferase Immunoenzyme Techniques Rats Sprague-Dawley Parasympathetic Nervous System Internal medicine medicine Animals Cholinergic neuron Fluorescent Antibody Technique Indirect Neurons Nucleus ambiguus General Neuroscience S100 Proteins Motor neuron Immunohistochemistry Choline acetyltransferase Rats Rhombencephalon Dorsal motor nucleus medicine.anatomical_structure Endocrinology nervous system Cholinergic Axotomy Neuroscience |
| Zdroj: | NeuroReport. 7:3093-3100 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199611250-00060 |
| Popis: | The double staining of S-100 beta and choline acetyltransferase (ChAT) revealed that S-100 beta immunoreactivity was localized in most, but not in all, cholinergic neurones in the somatomotor nuclei of the cranial nerves and in the ambiguus nucleus. S-100 beta was present in almost all cholinergic neurones in the brain stem reticular, red, vestibular (excluding medial), mesencephalic trigeminal and cerebellar nuclei. However, S-100 beta immunoreactivity was lacking in cholinergic neurones in the parabrachial complex, the dorsal motor nucleus of the vagal nerve and most sensory nuclei. No S-100 beta-positive neurones lacked ChAT immunoreactivity. Taken together with the fact that the vulnerability of motoneurones to axotomy is markedly reduced in the first 3 postnatal weeks, during which period neuronal S-100 beta appears and increases, a possible effect of S-100 beta on the survival of cholinergic motoneurones may be suggested. |
| Databáze: | OpenAIRE |
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