Restin in Hodgkin's Disease and Anaplastic Large Cell Lymphoma
| Autor: | De Wolf-Peeters C, Josef Brüggen, Jan Delabie, Van Leuven F, G. Bilbe |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty CD30 Biology Intermediate Filament Proteins immune system diseases hemic and lymphatic diseases medicine Humans Anaplastic lymphoma kinase Neoplastic transformation Reed-Sternberg Cells Anaplastic large-cell lymphoma Chromosomes Human Pair 12 Cell growth Chromosome Mapping Hematology medicine.disease Hodgkin Disease Neoplasm Proteins Lymphoma Cell Transformation Neoplastic Oncology Reed–Sternberg cell Lymphoma Large B-Cell Diffuse REL Microtubule-Associated Proteins |
| Zdroj: | Leukemia & Lymphoma. 12:21-26 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199309059567 |
| Popis: | We recently characterized a novel putative intermediate-filament associated protein which is strongly expressed in the Reed-Sternberg cells of Hodgkin's disease. Therefore we named the protein ‘restin’, an acronym for Reed-Sternberg cell intermediate filament-associated protein. The protein is also expressed in anaplastic large cell lymphoma or Ki-1 lymphoma, a non-Hodgkin's lymphoma phenotypically related to Hodgkin's disease. Although the functions of restin are not yet fully elucidated, transfection experiments demonstrate that over-expression of the protein increases cell growth by a mechanism which may involve upregulation of the transferrin receptor. Hence, restin may contribute to neoplastic transformation in Hodgkin's disease and anaplastic large cell lymphoma. Study of the mechanisms leading to restin overexpression may provide important data on the etiology of Hodgkin's disease and its relation to anaplastic large cell lymphoma. |
| Databáze: | OpenAIRE |
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