Two distinct molecular subtypes of chronic lymphocytic leukemia give new insights on the pathogenesis of the disease and identify novel therapeutic targets
| Autor: | M A Piris, Aránzazu García-Raso, Pilar Llamas, Margarita Sánchez-Beato, José A. García-Marco, Raul Cordoba, Beatriz Herreros, Joaquin Martinez-Lopez, Elena Domenech, Juan-F Garcia, Antonia Rodriguez |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Chronic lymphocytic leukemia Biopsy Disease Biology Pathogenesis 03 medical and health sciences hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols medicine Biomarkers Tumor Cluster Analysis Humans Molecular Targeted Therapy Lymph node Gene Aged Neoplasm Staging Aged 80 and over Gene Expression Profiling breakpoint cluster region Computational Biology Hematology Cell cycle Middle Aged medicine.disease Prognosis Leukemia Lymphocytic Chronic B-Cell 030104 developmental biology medicine.anatomical_structure Oncology Immunology PAX5 Female Lymph Nodes Signal Transduction |
| Zdroj: | Leukemialymphoma. 57(1) |
| ISSN: | 1029-2403 |
| Popis: | Biopsy samples of lymph nodes from 38 patients with CLL were analyzed. We found differential expression in 1092 genes in two different subgroups: 418 overexpressed in one subgroup and 674 in another. Molecular pathways identified in one subgroup appear to be characterized by greater dependence of signaling by cytokines and activation of the NFkB pathway, while in the other seem to depend on cell cycle. Despite having found a differential expression between both subgroups, none of these genes reached FDR < 0.25. We have not found significant association with survival or any prognostic factors. Analysis of the differences between normal lymph node and CLL in 253 genes with difference in the intensity of expression revealed upregulated genes different to BCR: CD40, TCL1, IL-7, and PAX5. Using large-scale molecular analysis, we may obtain information about molecular mechanisms of CLL pathogenesis and may contribute to the identification of new therapeutic targets. |
| Databáze: | OpenAIRE |
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