Air pollution and allergy: experimental studies on modulation of allergen release from pollen by air pollutants
| Autor: | J Tomczok, K H Friedrichs, Johannes Ring, H. Behrendt, C. Fritzsche, Wolf-Meinhard Becker, W Sliwa-Tomczok |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Allergy
Ozone Immunology Air pollution medicine.disease_cause chemistry.chemical_compound Allergen Air pollutants Pollen Botany otorhinolaryngologic diseases medicine Hypersensitivity Immunology and Allergy Humans Pollutant Air Pollutants food and beverages Humidity General Medicine medicine.disease respiratory tract diseases chemistry Environmental chemistry Environmental science |
| Zdroj: | International archives of allergy and immunology. 113(1-3) |
| ISSN: | 1018-2438 |
| Popis: | The fact that allergic diseases increase in prevalence is a generally accepted and worldwide phenomenon. The causes for this increase are not known: only hypothetical concepts exist. Epidemiological studies comparing Eastern and Western European populations have shown a striking difference in the prevalence of respiratory atopic diseases, which is lower in the East. At the same time, different patterns of air pollution have been described, namely 'classical' type I, characterized by SO2 and dust prevailing in the East, and 'modern' type II, characterized by organic compounds, fine particles and ozone, which is more prominent in the West. Type II was associated in multivariate regression analysis with increased prevalence of IgE-mediated allergy. Pollen grains collected from industrial regions with high polyaromatic hydrocarbon load in West Germany, but not in East Germany, were shown to be agglomerated with airborne particles. In vitro exposure of pollen to particles indicated morphological changes and increased allergen release from the pollen. In vitro exposure of pollen to gaseous pollutants (SO2 and NO2) under different conditions of humidity resulted in SO2-induced, but not NO2-induced reduction of allergen release from pollen. It is concluded that the bioavailability of grass pollen allergens may be modulated by air pollutants, supporting the concept of an interaction between pollen and pollutants in the atmosphere outside the organism which in turn may affect allergy-relevant phenomena. |
| Databáze: | OpenAIRE |
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