Role of Spirulina in mitigating hemato-toxicity in Swiss albino mice exposed to aluminum and aluminum fluoride
| Autor: | K. P. Sharma, Subhasini Sharma, Shweta Sharma |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Aluminum fluoride Health Toxicology and Mutagenesis 010501 environmental sciences Body weight 01 natural sciences Phosphates Toxicology 03 medical and health sciences chemistry.chemical_compound Fluorides Mice Random Allocation Animal science Spirulina Environmental Chemistry Ecotoxicology Animals Spirulina (dietary supplement) Aluminum Compounds 0105 earth and related environmental sciences Random allocation Chemistry Toxicity Tests Subchronic General Medicine Pollution 030104 developmental biology Blood Toxicity Tests Subacute Toxicity Dietary Supplements Chemically-Induced Disorders Fluoride Aluminum |
| Zdroj: | Environmental science and pollution research international. 23(24) |
| ISSN: | 1614-7499 |
| Popis: | Aluminum is ingested through foods, water, air, and even drugs. Its intake is potentiated further through foods and tea prepared in aluminum utensils and Al salt added in the drinking water for removal of suspended impurities and also fluoride in the affected areas. The ameliorating role of a blue green alga Spirulina is well documented to various pollutants in the animal models. We, therefore, examined its protective role (230 mg/kg body weight) on the hematology of male Swiss albino mice treated with aluminum (sub-acute = 78.4 mg/kg body weight for 7 days, sub-chronic = 7.8 mg/kg body weight for 90 days) and aluminum fluoride (sub-acute = 103 mg/kg body weight, sub-chronic = 21 mg/kg body weight), along with their recovery after 90 days of sub-chronic exposure. This study revealed significant reduction in the values of RBC (5-18 %), Hb (15-17 %), PCV (8-14 %), and platelets (26-36 %), and increase in WBC (54-124 %) in the treated mice, particularly after sub-acute exposure. Aluminum fluoride was comparatively more toxic than aluminum. Further, Spirulina supplement not only alleviated toxicity of test chemicals in Swiss albino mice but also led to their better recovery after withdrawal. |
| Databáze: | OpenAIRE |
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