Multimodal Imaging and Choroidal Volumetric Changes After Half-fluence PDT in Central Serous Chorioretinopathy

Autor: Amani A. Fawzi, Ronil S. Shah, Lee M. Jampol, Dina Baddar, Marion R. Munk, Frankie Pappas, Brandon J. Wong
Rok vydání: 2015
Předmět:
Male
Visual acuity
genetic structures
medicine.medical_treatment
Visual Acuity
Photodynamic therapy
Multimodal Imaging
chemistry.chemical_compound
0302 clinical medicine
Fluorescein Angiography
Coloring Agents
Photosensitizing Agents
medicine.diagnostic_test
Middle Aged
Fluorescein angiography
Sensory Systems
Serous fluid
medicine.anatomical_structure
Central Serous Chorioretinopathy
Female
medicine.symptom
Tomography
Optical Coherence
Adult
Indocyanine Green
medicine.medical_specialty
Porphyrins
Capillary Permeability
03 medical and health sciences
Cellular and Molecular Neuroscience
Ophthalmology
medicine
Humans
Retrospective Studies
Multimodal imaging
Choroid
business.industry
Verteporfin
eye diseases
Surgery
Cross-Sectional Studies
Photochemotherapy
chemistry
Angiography
030221 ophthalmology & optometry
sense organs
business
Indocyanine green
030217 neurology & neurosurgery
Zdroj: Current Eye Research. 41:97-106
ISSN: 1460-2202
0271-3683
DOI: 10.3109/02713683.2014.1002047
Popis: The purpose of this study was to identify SD-OCT changes that correspond to leakage on fluorescein (FA) and indocyanine angiography (ICGA) and evaluate effect of half-fluence photodynamic therapy (PDT) on choroidal volume in chronic central serous choroidoretinopathy (CSC).Retrospective analysis of patients with chronic CSC who had undergone PDT. Baseline FA and ICGA images were overlaid on SD-OCT to identify OCT correlates of FA or ICGA hyperfluorescence. Choroidal volume was evaluated in a subgroup of eyes before and after PDT.Twenty eyes were evaluated at baseline, of which seven eyes had choroidal volume evaluations at baseline and 3 months following PDT. SD-OCT changes corresponding to FA hyperfluorescence were subretinal fluid (73%), RPE microrip (50%), RPE double-layer sign (31%), RPE detachment (15%), and RPE thickening (8%). ICGA hyperfluoresence was correlated in 93% with hyperreflective spots in the superficial choroid. Choroidal volume decreased from 9.35 ± 1.99 to 8.52 ± 1.92 and 8.04 ± 1.7 mm(3) (at 1 and 3 months post PDT, respectively, p ≤ 0.001).We identified specific OCT findings that correlate with FA and ICGA leakage sites. SD-OCT is a valuable tool to localize CSC lesions and may be useful to guide PDT treatment. Generalized choroidal volume decrease occurs following PDT and extends beyond PDT treatment site.
Databáze: OpenAIRE
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