The impact of chlorhexidine gluconate bathing on skin bacterial burden of neonates admitted to the Neonatal Intensive Care Unit

Autor: Tracy L. Ross, Susan W. Aucott, Karen C. Carroll, Aaron M. Milstone, Elizabeth Colantuoni, Julia Johnson, Nuntra Suwantarat
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
Neonatal intensive care unit
Bathing
Bacterial growth
medicine.disease_cause
Article
03 medical and health sciences
0302 clinical medicine
chlorhexidine gluconate
Intensive Care Units
Neonatal
030225 pediatrics
Intensive care
Internal medicine
Outcome Assessment
Health Care
Chlorhexidine gluconate
Secondary Prevention
medicine
Humans
Prospective Studies
030212 general & internal medicine
Child
Prospective cohort study
Skin
Cross Infection
Groin
business.industry
Chlorhexidine
Infant
Newborn
Obstetrics and Gynecology
Baths
Staphylococcal Infections
infection control
neonatal intensive care unit
Bacterial Load
3. Good health
medicine.anatomical_structure
Staphylococcus aureus
Catheter-Related Infections
Pediatrics
Perinatology and Child Health
Intensive Care
Neonatal
Anti-Infective Agents
Local
Female
business
Infant
Premature
Zdroj: Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
0743-8346
Popis: Objective: To assess the impact of chlorhexidine gluconate (CHG) bathing on skin bacterial burden in neonates Study Design: In this prospective observational study, arm and groin skin bacterial growth was measured in 40 CHG-exposed and non-exposed neonates admitted to the NICU. Exposed neonates received 2% CHG baths per protocol for central line-associated bloodstream infection (CLABSI) prevention or Staphylococcus aureus decolonization. Results: Forty neonates were enrolled, 18 of whom were CHG-exposed. Mean baseline Gram-positive (GP) bacterial burden was 2.19 log CFU/ml on the arm and 1.81 log CFU/ml on the groin. Bacterial burden decreased after the first bath, but returned to baseline by 72 hours. Residual skin CHG concentration declined over time, with a corresponding increase in GP bacterial burden. Conclusions: CHG bathing reduces skin bacterial burden, but burden returns to baseline after 72 hours. Twice weekly CHG bathing may be inadequate to suppress skin bacterial growth in hospitalized neonates.
Databáze: OpenAIRE
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