Increased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement
| Autor: | Del Rosso, A, Distler, O, Milia, A, Emanueli, C, Ibba-Manneschi, L, Guiducci, S, Conforti, M, Generini, S, Pignone, A, Gay, S, Madeddu, P, Matucci-Cerinic, M |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Systemic disease Pathology medicine.medical_specialty Endothelium Immunology Tissue kallikrein General Biochemistry Genetics and Molecular Biology Microscopic Angioscopy Microcirculation Immunoenzyme Techniques Rheumatology immune system diseases medicine Humans Immunology and Allergy cardiovascular diseases skin and connective tissue diseases Serpins Aged Autoantibodies Skin Autoimmune disease Scleroderma Systemic integumentary system urogenital system business.industry Middle Aged medicine.disease Connective tissue disease biological factors Capillaries Extended Report medicine.anatomical_structure Kallistatin Immunohistochemistry Female Endothelium Vascular Carrier Proteins business Tissue Kallikreins circulatory and respiratory physiology |
| Zdroj: | Annals of the Rheumatic Diseases. 64:382-387 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2004.023382 |
| Popis: | Background: In systemic sclerosis (SSc) the lack of an angiogenic response to hypoxia may be due to inappropriate synthesis of angiogenic and angiostatic factors. Tissue kallikrein (t-kallikrein), regulating the kallikrein-kinin system and acting on the microcirculation, is a potent angiogenic agent, and kallistatin is its natural inhibitor. Objective: To evaluate, in patients with SSc, t-kallikrein and kallistatin levels and their correlation with clinical features and measures of microvascular involvement. Patients and methods: Serum levels of t-kallikrein and kallistatin (ELISA) and t-kallikrein skin expression (immunohistochemistry) were studied in patients with SSc, and evaluated for subset (dSSc or lSSc), clinical and immunological features, and microvascular involvement (ulcers, telangiectasias, nailfold videocapillaroscopy). Results: Circulating levels of t-kallikrein were higher in SSc than in controls (p |
| Databáze: | OpenAIRE |
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