Anti-proliferative effects of qianliening capsules on prostatic hyperplasia in vitro and in vivo

Autor: Jianheng Zhou, Zhenfeng Hong, Xiaoyong Zhong, Jiumao Lin, Wei Xu
Rok vydání: 2015
Předmět:
Male
Cancer Research
medicine.medical_specialty
Cell Survival
proliferation
Basic fibroblast growth factor
Cell
Prostatic Hyperplasia
cyclin D1
Capsules
Biology
Pharmacology
Biochemistry
Cell Line
Rats
Sprague-Dawley
chemistry.chemical_compound
In vivo
Proliferating Cell Nuclear Antigen
Internal medicine
Genetics
medicine
Animals
Molecular Biology
Cell Proliferation
benign prostatic hyperplasia
cyclin-dependent kinase 4
Cell growth
qianliening capsules
Prostate
Articles
Cell cycle
Hyperplasia
medicine.disease
G1 Phase Cell Cycle Checkpoints
Rats
Proliferating cell nuclear antigen
Disease Models
Animal
Endocrinology
medicine.anatomical_structure
Oncology
chemistry
S Phase Cell Cycle Checkpoints
biology.protein
Finasteride
Molecular Medicine
Fibroblast Growth Factor 2
Drugs
Chinese Herbal
Signal Transduction
Zdroj: Molecular Medicine Reports
ISSN: 1791-3004
1791-2997
DOI: 10.3892/mmr.2015.3566
Popis: Previous studies by our group showed that Qianliening capsules (QC), a clinically proven effective traditional Chinese formulation that has long been used in the treatment of benign prostatic hyperplasia (BPH), is capable of inhibiting BPH in vivo and in vitro via the promotion of apoptosis, suppression of the EGFR/STAT3 signaling pathway and regulating the expression of sex hormones as well as their receptors. However, the mechanism of its anti-BPH activity has remained to be fully elucidated. The present study aimed to investigate the mechanism underlying the anti-proliferative effect of QC in vivo and in vitro. Castrated male Sprage-Dawley (SD) rats where subcutaneously injected with testosterone propionate and the WPMY-1 cell line was stimulated with basic fibroblast growth factor in order to generate BPH in vivo and in vitro separately, both of which were then subjected to QC treatment. Finasteride was used as a positive control drug for the in vivo study. In the present study, it was found that treatment with QC or finasteride significantly reduced the prostatic index (PI=prostate wet weight/body weight × 100) in a rat model of BPH (P
Databáze: OpenAIRE
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