Plasmodium berghei: Selective release of 'protective' antigens
| Autor: | E. H. van Elven, Lambert G. Poels, Catherine C. van Niekerk, Magda A. M. Franken |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Reticulocytes
Plasmodium berghei Immunology Spleen Parasitemia Biology Active immunization Mice Immune system Antigen parasitic diseases medicine Animals Antigens Mice Inbred BALB C Immune Sera Immunization Passive Chloroquine General Medicine biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification Virology Malaria Immunity Active Infectious Diseases medicine.anatomical_structure Immunization Antibody Formation biology.protein bacteria Parasitology Antibody |
| Zdroj: | Experimental Parasitology. 42:182-193 |
| ISSN: | 0014-4894 |
| DOI: | 10.1016/0014-4894(77)90076-5 |
| Popis: | BALB c mice infected with Plasmodium berghei produced high levels of immunoglobulins after the first peak parasitemia at which time the malaria parasites were mainly present in reticulocytes and not in oxyphilic red blood cells. Attempts at active immunization with intact parasitized reticulocytes were successful, while immunization with parasitized oxyphilic erythrocytes failed completely. The antibodies produced in response to immunization reacted with free parasites and penetrated only those reticulocytes which were infected with three to four larger parasites. Although the first peak mortality in acute infection was prevented with immune serum, the infection could not be aborted by immune serum or spleen cells. Nevertheless, in 40% of syngeneic mice protection was transferred by giving them multiple injections of immune spleen cells during a period of 4 weeks prior to infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|