A case of intractable epilepsy positive for the detection of measles virus genome in the cerebrospinal fluid and peripheral mononuclear cells using reverse transcriptase-polymerase chain reaction
| Autor: | Leipin Yuan, Keiko Kinoue, Kouji Takekuma, Akinori Hoshika, Masaaki Ogihara, Hisashi Kawashima, Tasuku Miyajima, Takayuki Mori |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Adolescent Paramyxoviridae Molecular Sequence Data Polymerase Chain Reaction Measles Peripheral blood mononuclear cell Virus Measles virus Developmental Neuroscience Morbillivirus medicine Humans DNA Primers Epilepsy Genome Base Sequence biology business.industry Viral Vaccines General Medicine biology.organism_classification medicine.disease Virology Reverse transcriptase Frontal Lobe DNA Viral Pediatrics Perinatology and Child Health Immunology Leukocytes Mononuclear Subacute Sclerosing Panencephalitis Neurology (clinical) Measles vaccine business |
| Zdroj: | Brain and Development. 18:220-223 |
| ISSN: | 0387-7604 |
| Popis: | We report a rare case of intractable frontal lobe epilepsy with mental deterioration, in which the measles virus gene was detected from the cerebrospinal fluid (CSF) and peripheral mononuclear cells (PBMC) obtained 9 years after the first epileptic episode using reverse transcriptase-polymerase chain reaction (RT-PCR). The patient had been immunized with an attenuated measles vaccine and had no history of clinically apparent acute measles infection. However the analysis of the sequence of the PCR product from CSF showed the circulating wild strain genotype at the time when the patient complained of his first epileptic episode. |
| Databáze: | OpenAIRE |
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