The Twin-Arginine Pathway for Protein Secretion
| Autor: | Jan Maarten van Dijl, Kelly M. Frain, Colin Robinson |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Arginine Bacillus subtilis Protein Sorting Signals medicine.disease_cause Microbiology Twin-arginine translocation pathway 03 medical and health sciences Escherichia coli medicine 030102 biochemistry & molecular biology biology Chemistry biology.organism_classification Cell biology Transport protein Protein Transport 030104 developmental biology Secretory protein Gene Products tat Proofreading Metabolic Networks and Pathways |
| Zdroj: | Protein Secretion in Bacteria |
| ISSN: | 2324-6200 |
| DOI: | 10.1128/ecosalplus.esp-0040-2018 |
| Popis: | The Tat pathway for protein translocation across bacterial membranes stands out for its selective handling of fully folded cargo proteins. In this review, we provide a comprehensive summary of our current understanding of the different known Tat components, their assembly into different complexes, and their specific roles in the protein translocation process. In particular, this overview focuses on the Gram-negative bacterium Escherichia coli and the Gram-positive bacterium Bacillus subtilis . Using these organisms as examples, we discuss structural features of Tat complexes alongside mechanistic models that allow for the Tat pathway’s unique protein proofreading and transport capabilities. Finally, we highlight recent advances in exploiting the Tat pathway for biotechnological benefit, the production of high-value pharmaceutical proteins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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