Curculigoside augments cell-mediated immune responses in metastatic tumor-bearing animals

Autor:	Girija Kuttan, Vishnu Priya Murali
Rok vydání:	2016
Předmět:	0301 basic medicine Male Immunology Toxicology Benzoates Proinflammatory cytokine Metastasis 03 medical and health sciences Curculigo Mice 0302 clinical medicine Immune system Glucosides medicine Immunology and Allergy Animals Humans Neoplasm Metastasis Cytotoxicity Pharmacology Curculigoside Antibody-dependent cell-mediated cytotoxicity Immunity Cellular Lung biology General Medicine Neoplasms Experimental medicine.disease biology.organism_classification Curculigo orchioides 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research Cytokines Heterografts K562 Cells
Zdroj:	Immunopharmacology and immunotoxicology. 38(4)
ISSN:	1532-2513
Popis:	A positive modulation of immune system is necessary for preparing the body to fight against malignant tumor cells. In the present study, the stimulatory effect of Curculigoside on cell-mediated immune response against the metastasis of B16F10 melanoma cells was analyzed in C57BL/6 mice. Curculigoside is a phenolic glucoside present in the plant Curculigo orchioides Gaertn. (Family - Amaryllidaceae). Administration of Curculigoside enhanced the natural killer (NK) cell activity, antibody-dependent cell-mediated cytotoxicity and complement-mediated cytotoxicity in metastatic tumor-bearing animals, when compared to the untreated control animals. The compound was also found to be effective in reducing the levels of proinflammatory cytokines such as TNF-α, IL-1β, IL-6 and GM-CSF during metastasis. Besides these, levels of TH1 cytokines, such as IL-2 and IFN-γ, were significantly enhanced (p 0.001) by Curculigoside administration and thereby reduces the metastatic lung colony formation along with an increased lifespan of the experimental animals. These studies provide an evidence for the stimulation of cell-mediated immune responses by Curculigoside against B16F10-induced metastatic tumor progression in experimental animals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc50c8c1076f83508d17eec6a4737275 https://pubmed.ncbi.nlm.nih.gov/27228189 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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