Interleukin 6 predicts increased neural response during face processing in a sample of individuals with schizophrenia and healthy participants: A functional magnetic resonance imaging study
| Autor: | Marcus Keynon, Laurena Holleran, Colm McDonald, Ross McManus, Sinead King, Derek W. Morris, Declan P. McKernan, David Mothersill, Karolina Rokita, Brian Hallahan, Aiden Corvin, John Kelly, Gary Donohoe, Saahithh Patlola, Maria R. Dauvermann |
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| Rok vydání: | 2021 |
| Předmět: |
CAMI
Centre for Advanced Medical Imaging Emotions FFA fusiform face area Audiology 0302 clinical medicine Feature (machine learning) Facial emotion recognition Brain Mapping medicine.diagnostic_test ACC anterior cingulate cortex SZ schizophrenia fMRI 05 social sciences ART Artefact Detection Tools Regular Article ELISA enzyme-linked immunosorbent assay Magnetic Resonance Imaging Healthy Volunteers Facial Expression IL-6 interleukin 6 IQ intelligence quotient Neurology Schizophrenia Facial Recognition psychological phenomena and processes medicine.medical_specialty Cognitive Neuroscience Computer applications to medicine. Medical informatics R858-859.7 Schizoaffective disorder Affect (psychology) Statistical parametric mapping behavioral disciplines and activities 050105 experimental psychology 03 medical and health sciences Neuroimaging LLP left lateral parietal Social cognition medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging RC346-429 STS superior temporal sulcus IL-6 Interleukin-6 business.industry mPFC medial prefrontal cortex SPM Statistical Parametric Mapping ERT emotion recognition task medicine.disease stomatognathic diseases DMN default mode network FWE family-wise error Neurology. Diseases of the nervous system Neurology (clinical) Functional magnetic resonance imaging business 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical NeuroImage Clinical NeuroImage: Clinical, Vol 32, Iss, Pp 102851-(2021) |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2021.102851 |
| Popis: | Highlights • IL-6 has been associated with poorer facial emotion recognition. • fMRI was performed during a faces task and IL-6 measured from blood samples. • IL-6 predicted increased neural response during facial emotion recognition. Background Deficits in facial emotion recognition are a core feature of schizophrenia and predictive of functional outcome. Higher plasma levels of the cytokine interleukin 6 (IL-6) have recently been associated with poorer facial emotion recognition in individuals with schizophrenia and healthy participants, but the neural mechanisms affected remain poorly understood. Methods Forty-nine individuals with schizophrenia or schizoaffective disorder and 158 healthy participants were imaged using functional magnetic resonance imaging during a dynamic facial emotion recognition task. Plasma IL-6 was measured from blood samples taken outside the scanner. Multiple regression was used in statistical parametric mapping software to test whether higher plasma IL-6 predicted increased neural response during task performance. Results Higher plasma IL-6 predicted increased bilateral medial prefrontal response during neutral face processing compared to angry face processing in the total sample (N = 207, tmax = 5.67) and increased left insula response during angry face processing compared to neutral face processing (N = 207, tmax = 4.40) (p |
| Databáze: | OpenAIRE |
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