Neutralization potential of the plasma of HIV-1 infected Indian patients in the context of anti-V3 antibody content and antiretroviral theraphy
| Autor: | SS Prakash, Kalpana Luthra, Raiees Andrabi, Rajesh Kumar, Anjali Hazarika, Ashutosh Biswas, Naveet Wig, Shubhasree Dutta Choudhury, Alok Choudhary |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Anti-HIV Agents Human immunodeficiency virus (HIV) India HIV Infections Context (language use) HIV Antibodies Biology medicine.disease_cause Applied Microbiology and Biotechnology Microbiology Neutralization Plasma Neutralization Tests Antiretroviral naive medicine Humans General Medicine Middle Aged Antibodies Neutralizing Antiretroviral therapy Virology Titer Immunology HIV-1 biology.protein Female Antibody |
| Zdroj: | The Journal of Microbiology. 50:149-154 |
| ISSN: | 1976-3794 1225-8873 |
| DOI: | 10.1007/s12275-012-1246-y |
| Popis: | We assessed the anti-V3 antibody content and viral neutralization potential of the plasma of 63 HIV-1-infected patients (antiretroviral naïve=39, treated=24) against four primary isolates (PIs) of clade C and a tier 1 clade B isolate SF162. Depletion and inhibition of anti-V3 antibodies in the plasma of five patients with high titers of anti-V3 antibodies led to modest change in the neutralization percentage against two PIs (range 0-21%). The plasma of antiretroviral-treated patients exhibited higher neutralization potential than that of the drug-naïve plasmas against the four PIs tested which was further evidenced by a follow-up study. |
| Databáze: | OpenAIRE |
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