Intensification Regimen for Advanced-Stage Resectable Hypopharyngeal Carcinoma
| Autor: | Amit Agrawal, John C. Grecula, David E. Schuller, Chris A. Rhoades, Enver Ozer |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Paclitaxel medicine.medical_treatment Laryngectomy Hypopharyngeal Carcinoma Percutaneous endoscopic gastrostomy Antineoplastic Combined Chemotherapy Protocols medicine Humans Prospective Studies Intraoperative radiation therapy Survival rate Aged Ohio Hypopharyngeal Neoplasms business.industry General Medicine Middle Aged Combined Modality Therapy Chemotherapy regimen Surgery Survival Rate Radiation therapy Regimen Treatment Outcome Otorhinolaryngology Feasibility Studies Patient Compliance Female Dose Fractionation Radiation Cisplatin business |
| Zdroj: | Archives of Otolaryngology–Head & Neck Surgery. 132:385 |
| ISSN: | 0886-4470 |
| Popis: | Objective To determine feasibility, compliance, long-term survival, and disease control rates in the intensification regimen for advanced resectable hypopharyngeal carcinoma. Design Prospective, nonrandomized, controlled phase 2 trial with a median follow-up period of 89 months (range, 3.4-140.0 months). Setting Cancer center at a state university. Patients Thirty-two patients (age range, 44-79 years; median age, 59 years) with advanced (69% stage IV, 31% stage III) resectable hypopharyngeal carcinoma. Interventions Combination of surgery, radiation therapy, and chemotherapy (cisplatin and paclitaxel) along with intraoperative radiation therapy. Main Outcome Measures Compliance, long-term survival, and locoregional and systemic disease control rates and functional outcome. Results The protocol compliance rate was 62% (20 of 32 patients), and the overall 5-year survival rate was 56%. Local recurrence occurred in 3 patients (9%). The systemic disease control rate was 91% (29 of 32 patients). Total laryngectomy was required in 15 patients (47%); preservation of the larynx was possible in 17 patients (53%). Only 3 (13%) of 6 patients were percutaneous endoscopic gastrostomy tube dependent in the long-term follow-up. Conclusions The intensification regimen described in this study accomplished excellent long-term survival and disease control rates in patients with advanced resectable hypopharyngeal carcinoma. The future plan is to proceed with a phase 3 trial if the single-institutional experience at The Ohio State University can be duplicated in a multi-institutional phase 2 study. |
| Databáze: | OpenAIRE |
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