Association of Plasma Pentraxin-3 Levels with Retinopathy and Systemic Factors in Diabetic Patients
| Autor: | Cuneyt Muderrisoglu, Pınar Akca Guler, Duygu Sak, Fusun Erdenen, Hulya Gungel, Muzaffer Ece Hakan Sahin, Hafize Uzun, Gonul Simsek, Esma Altunoglu, Atakan Koro |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Blood Pressure Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine medicine Humans Endothelial dysfunction Pentraxin-3 Aged Aged 80 and over Inflammation Diabetic Retinopathy biology Vascular inflammation business.industry C-reactive protein Type 2 Diabetes Mellitus Diabetic retinopathy Middle Aged medicine.disease Serum Amyloid P-Component 030104 developmental biology C-Reactive Protein Diabetes Mellitus Type 2 Case-Control Studies 030221 ophthalmology & optometry biology.protein Disease Progression Female business Biomarkers Retinopathy |
| Zdroj: | Metabolic syndrome and related disorders. 16(7) |
| ISSN: | 1557-8518 |
| Popis: | Diabetic retinopathy (DR) is mainly caused by metabolic factors, vascular inflammation, and endothelial dysfunction. We aimed to evaluate the relationship of DR with inflammatory and biochemical alterations in type 2 diabetics.A total of 89 diabetic patients with retinopathy [(DR (+) (n = 30)], without retinopathy [(DR (-) (n = 32)], and 27 control subjects were involved in the study. Demographic properties, biochemical values, ophtalmologic evaluation, C-reactive protein (CRP), and pentraxin-3 (PTX-3) levels were recorded.There was significant difference between controls, DR (-) and DR (+) groups with regard to serum PTX-3 levels. Control group had the lowest and DR (+) group revealed the highest PTX-3 levels. Severity of retinopathy was not related with CRP or PTX-3 levels. Duration of diabetes was longer, systolic blood pressure (SBP) and urinary albumin-creatinine ratio (UACR) were significantly higher in DR (+) subjects than DR (-) subjects. Multivariate analysis revealed that PTX-3 level and SBP were the variables that had a significant effect on DR (P = 0.002, OR = 1.61, and P = 0.021, OR = 1.06, respectively).Plasma PTX-3 levels may be a valuable predictor of DR-like factors such as duration of diabetes, hypertension, and UACR. Although inflammation has an important role in DR, we think that biomarkers reflecting inflammation is not sufficient to predict development and progression of DR; but follow up with PTX-3 levels along with ophthalmological evaluation may be useful. A single determination may not reflect the variations over time, so repeat measures may provide knowledge if PTX-3 is just a biomarker or has a causal role. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|