Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China

Autor:	K P Jiang, P Zhang, Q He, Yueqiu Gao, Xiaoming Wang, B Chen, Q K Wu, Z Y Yang, B J Lu, Y F Xing, G J Tian, X L Chi, J C Guo, You Zhou, Y Q Mi, Chengzhong Li, N N Sun, J H Wu, J D Xue, X L Luo, H B Du, Zuojiong Gong, H Guo, F Jiang, W Lu, H Z Yang, D Q Zhou, Fei Li, Xiaomei Li, Y T Jiao, J M Jiang, F. Li, Z B Hu, L C Wang, W B Shi, X H Sun, P Guo, Y A Ye, H Jin, M X Zhang, G D Tong, C B Wang, Z H Zhou, Y J Zheng, X Z Yang, X Deng, D W Mao, L. S. Wang, Y Li, W Q Shi, Q. J. Li, Hui Wang, X Y Hu, X W Zhang, X K Li, G Zhao
Rok vydání:	2018
Předmět:	0301 basic medicine Adult Liver Cirrhosis Male Serum medicine.medical_specialty HBsAg China Disease medicine.disease_cause Hepatitis b surface antigen Gastroenterology 03 medical and health sciences Young Adult 0302 clinical medicine Hepatitis B Chronic Fibrosis Virology Internal medicine medicine Humans Hepatitis B e Antigens Hepatitis B virus Hepatitis B Surface Antigens Hepatology business.industry virus diseases Alanine Transaminase Hepatitis B Middle Aged medicine.disease digestive system diseases Confidence interval 030104 developmental biology Infectious Diseases HBeAg DNA Viral 030211 gastroenterology & hepatology Female business
Zdroj:	Journal of viral hepatitis. 25(9)
ISSN:	1365-2893
Popis:	The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. We aimed to investigate the factors affecting HBsAg titres, using data from multicentre, large-sized clinical trials in China. The baseline data of 1795 patients in 3 multicentre trials were studied, and the patients were classified into 3 groups: hepatitis B early antigen (HBeAg)-positive chronic HBV infection (n = 588), HBeAg-positive chronic hepatitis B (n = 596), and HBeAg-negative chronic hepatitis B (n = 611). HBsAg titres in the different phases were compared, and multiple linear progression analyses were performed to investigate the implicated factors. HBsAg titres varied significantly in different phases (P = .000), with the highest (4.60 log10 IU/mL [10%-90% confidence interval: 3.52 log10 IU/mL-4.99 log10 IU/mL]) in patients with HBeAg-positive chronic HBV infection. In all phases, age and HBV DNA were correlated with serum HBsAg level. In HBeAg-positive chronic hepatitis B patients, a negative correlation between HBsAg titres and fibrosis stage was observed. Alanine amonitransferase or necroinflammatory activity was also correlated with HBsAg titres in HBeAg-negative chronic hepatitis B patients. In conclusion, decreased HBsAg titres may be associated with advancing fibrosis in HBeAg-positive chronic hepatitis B patients or increased necroinflammation in those with HBeAg-negative chronic hepatitis B. Our findings may help clinicians better understand the kinetics of HBsAg and provide useful insights into the management of this disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4b5c8fe2f4895219dd300e3fc63a07 https://pubmed.ncbi.nlm.nih.gov/29624802 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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