The effect of tartrazine on histamine release from rat peritoneal mast cells
| Autor: | R.J. Safford, B.F.J. Goodwin |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Immunology Egg albumin Ionophore chemistry.chemical_element Calcium In Vitro Techniques Histamine Release chemistry.chemical_compound Antigen Internal medicine medicine Animals Ascitic Fluid p-Methoxy-N-methylphenethylamine Drug Interactions Mast Cells Inhibitory effect Calcimycin Tartrazine Pharmacology Rats Inbred Strains Rats Endocrinology chemistry Azo Compounds Histamine |
| Zdroj: | International journal of immunopharmacology. 6(3) |
| ISSN: | 0192-0561 |
| Popis: | The release of histamine from purified rat peritoneal mast cells induced by specific antigen (egg albumin), compound 48/80 and calcium ionophore A23187 was modified by tartrazine. Histamine release induced by 48/80 and antigen was inhibited by the presence of 10(-5) to 10(-2)M tartrazine. The inhibitory effect on egg albumin induced histamine release was maximal when the tartrazine was added simultaneously with egg albumin, and was reduced by increased preincubation of the cells with tartrazine. Tartrazine had a small inhibitory effect on ionophore induced release at high concentrations, but augmented histamine release at tartrazine concentrations of 10(-3) and 10(-4)M. Augmentation of ionophore induced release was maximal at between 0-5 min preincubation of the cells with tartrazine. |
| Databáze: | OpenAIRE |
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