Sorocenols G and H, anti-MRSA oxygen heterocyclic Diels-Alder-type adducts from Sorocea muriculata roots
| Autor: | Yuanqing Ding, Susan P. Manly, Samir A. Ross, Xing-Cong Li, Raquel Rodríguez-Guzmán, Melissa R. Jacob, Mohamed M. Radwan, Daneel Ferreira |
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| Rok vydání: | 2008 |
| Předmět: |
Staphylococcus aureus
Antifungal Agents Stereochemistry Pharmaceutical Science Microbial Sensitivity Tests medicine.disease_cause Moraceae Plant Roots Analytical Chemistry Aspergillus fumigatus Adduct chemistry.chemical_compound Inhibitory Concentration 50 Drug Discovery Candida albicans Peru Stilbenes medicine Benzofurans Pharmacology Cryptococcus neoformans biology Molecular Structure Plant Extracts Organic Chemistry Sorocea biology.organism_classification Oxyresveratrol Anti-Bacterial Agents Oxygen Complementary and alternative medicine chemistry Molecular Medicine Methicillin Resistance Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of natural products. 71(10) |
| ISSN: | 1520-6025 |
| Popis: | Bioassay-guided fractionation of a root extract of Sorocea muriculata led to the isolation and identification of two new oxygen heterocyclic Diels-Alder-type adducts, sorocenols G (1) and H (2), along with lupeol-3-(3' R-hydroxytetradecanoate) and oxyresveratrol. The structures of 1 and 2 were elucidated using 1D and 2D NMR spectroscopic and HRMS data and by comparison with reported values. The absolute configurations of 1 and 2 were established by analysis of their experimental and theoretically calculated CD spectra. Compounds 1 and 2 showed significant and selective activity against methicillin-resistant Staphylococcus aureus with IC50 values of 1.5 and 0.5 microM, respectively. Compound 2 also displayed antifungal activity against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, with IC 50 values of 5.4, 5.4, and 10.0 microM, respectively. |
| Databáze: | OpenAIRE |
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