Clinical benefits of dexmedetomidine versus propofol in adult intensive care unit patients: a meta-analysis of randomized clinical trials
| Autor: | Shu-Qin Chen, Zhi-Qiu Xia, Xi Yao, Ke-Xuan Liu, Shi-Hong Wen, Chuan-Bo Xie |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
business.industry Critical Illness Sedation Intensive care unit law.invention Intensive Care Units Randomized controlled trial law Relative risk Intensive care Anesthesia medicine Humans Hypnotics and Sedatives Delirium Surgery Dexmedetomidine medicine.symptom Propofol business Randomized Controlled Trials as Topic medicine.drug |
| Zdroj: | Journal of Surgical Research. 185:833-843 |
| ISSN: | 0022-4804 |
| Popis: | Background: This meta-analysis was performed to assess the influence of dexmedetomidine and propofol for adult intensive care unit (ICU) sedation, with respect to patient outcomes and adverse events. Materials and methods: A systematic review was conducted of all randomized controlled trials exploring the clinical benefits of dexmedetomidine versus propofol for sedation in adult intensive care patients. The primary outcomes of this study were length of ICU stay, duration of mechanical ventilation, and risk of ICU mortality. Secondary outcomes included risk of delirium, hypotension, bradycardia and hypertension. Results: Ten randomized controlled trials, involving 1202 patients, were included. Dexmedetomidine significantly reduced the length of ICU stay by |
| Databáze: | OpenAIRE |
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