Synthesis of 4,6-diarylpyrimidin-2(1H)-one derivatives from benzyl halides and (1-bromoethyl)benzene under solvent-free conditions
Autor: | Mallappa Beerappa, Kalegowda Shivashankar |
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Rok vydání: | 2018 |
Předmět: | |
Zdroj: | Synthetic Communications. 48:2150-2158 |
ISSN: | 1532-2432 0039-7911 |
DOI: | 10.1080/00397911.2018.1479757 |
Popis: | A facile synthesis of a series of pyrimidinone derivatives from the reaction of benzyl halides, (1-bromoethyl)benzene and urea in the presence of pyridine N-oxide (PNO) under solvent-free conditions is described. This transformation presumeably occurs via oxidation/cross-aldol condensation/Michael addition/intra molecular cyclization, domino sequence, involving the formation of one C–C bond and two C–N bonds in a single step. Pyridine N-oxide (PNO) has been demonstrated to be efficient and mild reagent for the one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) from a variety of benzyl halides and (1-bromoethyl)benzene instead of benzaldehydes and acetophenone respectively with short reaction times and excellent yields. |
Databáze: | OpenAIRE |
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