Synthesis of 4,6-diarylpyrimidin-2(1H)-one derivatives from benzyl halides and (1-bromoethyl)benzene under solvent-free conditions

Autor: Mallappa Beerappa, Kalegowda Shivashankar
Rok vydání: 2018
Předmět:
Zdroj: Synthetic Communications. 48:2150-2158
ISSN: 1532-2432
0039-7911
DOI: 10.1080/00397911.2018.1479757
Popis: A facile synthesis of a series of pyrimidinone derivatives from the reaction of benzyl halides, (1-bromoethyl)benzene and urea in the presence of pyridine N-oxide (PNO) under solvent-free conditions is described. This transformation presumeably occurs via oxidation/cross-aldol condensation/Michael addition/intra molecular cyclization, domino sequence, involving the formation of one C–C bond and two C–N bonds in a single step. Pyridine N-oxide (PNO) has been demonstrated to be efficient and mild reagent for the one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) from a variety of benzyl halides and (1-bromoethyl)benzene instead of benzaldehydes and acetophenone respectively with short reaction times and excellent yields.
Databáze: OpenAIRE
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