Onset of action of captopril, enalapril, enalaprilic acid and lisinopril in normal man
| Autor: | A. M. M. Cumming, J. J. Morton, P. F. Semple, P. A. Meredith |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Captopril Enalaprilat Angiotensin-Converting Enzyme Inhibitors Blood Pressure Pharmacology Enalapril Heart Rate Lisinopril Reference Values Internal medicine Renin–angiotensin system medicine Humans Pharmacology (medical) cardiovascular diseases biology business.industry Hemodynamics Angiotensin-converting enzyme General Medicine Angiotensin II Endocrinology biology.protein Onset of action Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | Cardiovascular Drugs and Therapy. 1:45-50 |
| ISSN: | 1573-7241 0920-3206 |
| DOI: | 10.1007/bf02125832 |
| Popis: | The effects of orally administered captopril, enalapril and lisinopril on plasma concentrations of angiotensin converting enzyme (ACE), angiotensin II (ANGII) and renin (PRC) were studied over a period of 6 hours in 6 normal subjects. A further 4 subjects received intravenous enalapril and enalaprilic acid (enalaprilat). Captopril (25 mg) by mouth caused a fall in pANGII that reached a nadir 30 to 40 minutes after administration but an effect was hardly apparent after 6 hours. Enalapril (10 mg) by mouth had less marked effects on pACE and pANGII with a decline in levels first apparent 1 hour after administration and the lowest levels reached between 3 and 6 hours. Lisinopril (10 mg) produced a progressive fall in pACE and pANGII from 1 hour to reach the lowest values 6 hours after treatment. Intravenous enalaprilat (5 mg) produced an immediate sustained fall in both pACE and pANGII but intravenous enalapril (7 mg) had a biphasic inhibitory effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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