Combined effects of age and dietary fat on beta 1-receptors and Ca2+ channels in rat hearts
| Autor: | V. E. Benediktsdottir, Sigmundur Gudbjarnason, E. Gudmundsdottir |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Aging Physiology Phospholipid Arachidonic Acids chemistry.chemical_compound Nitrendipine Physiology (medical) Internal medicine Receptors Adrenergic beta medicine Animals Receptor chemistry.chemical_classification Chemistry Myocardium Cell Membrane Heart Rats Inbred Strains Cod liver oil Dietary Fats Rats Endocrinology Dihydroalprenolol Fatty Acids Unsaturated Arachidonic acid Calcium Channels Cardiology and Cardiovascular Medicine Corn oil Polyunsaturated fatty acid medicine.drug |
| Zdroj: | The American journal of physiology. 260(1 Pt 2) |
| ISSN: | 0002-9513 |
| Popis: | Male Wistar rats were fed a standard diet or diets supplemented with 10% butter, 10% corn oil, or 10% cod liver oil from the age of 2 mo. At 7 and 24 mo of age, the fatty acid composition of total phospholipids was determined in ventricular crude sarcolemma preparations; binding capacity and affinity (1/Kd) of [3H]dihydroalprenolol and [3H]nitrendipine binding were also determined. The arachidonic acid level was significantly higher at 24 mo than at 7 mo of age in the membrane phospholipids in rats fed no extra fat, but in rats fed fat-supplemented diets, age had no effect. Affinity of Ca2+ channels for [3H]nitrendipine decreased significantly in all dietary groups between 7 and 24 mo of age, whereas the affinity of beta 1-receptors for [3H]dihydroalprenolol increased in corn oil-fed rats. Density of beta 1-receptors decreased significantly in corn oil- and butter-fed rats and rats fed no extra fat between 7 and 24 mo of age, whereas the density of Ca2+ channels decreased significantly in corn oil-fed rats. We conclude that the antagonist binding properties of Ca2+ channels and beta 1-adrenergic receptors in rat hearts may change with age depending on the dietary fat. |
| Databáze: | OpenAIRE |
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