Inhibition of Angiotensin II- and Potassium-Mediated Aldosterone Secretion by KN-62 Suggests Involvement of Ca2+-Calmodulin-Dependent Protein Kinase II in Aldosterone Secretion
| Autor: | Ling Li, M. Haxton, Arunabha Ganguly |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Calmodulin Biophysics chemistry.chemical_element Calcium Biochemistry Piperazines KN-62 chemistry.chemical_compound 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Internal medicine medicine Animals Secretion Aldosterone Molecular Biology Cells Cultured Sulfonamides Angiotensin II receptor type 1 Dose-Response Relationship Drug biology Angiotensin II Cell Biology Isoquinolines Kinetics Endocrinology medicine.anatomical_structure chemistry Zona glomerulosa Calcium-Calmodulin-Dependent Protein Kinases Potassium biology.protein Cattle Zona Glomerulosa |
| Zdroj: | Biochemical and Biophysical Research Communications. 209:916-920 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1995.1585 |
| Popis: | Calcium is now acknowledged to play a major role as a cellular mediator of aldosterone secretion. However, the intricacies of the involvement of calcium in aldosterone secretion have not been clearly defined. We have shown here that calmodulin-dependent kinase II is involved in angiotensin II- and potassium-evoked aldosterone secretion as judged by the marked inhibitory effect of KN-62, a specific inhibitor of such a kinase, on aldosterone secretion and this inhibition was similar to that produced by calmodulin inhibitor, W-7. These results further strengthen the case for the participatory role of calcium-calmodulin system in aldosterone secretion. |
| Databáze: | OpenAIRE |
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