Expression of endoglin (CD105) in cervical cancer
| Autor: | Cornelis F. M. Sier, Arko Gorter, Gemma G. Kenter, H. J. M. A. A. Zijlmans, Suzanne Hazelbag, Gert Jan Fleuren, E.J. Dreef |
|---|---|
| Přispěvatelé: | Obstetrics and Gynaecology |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Vascular Endothelial Growth Factor A Cancer Research Pathology medicine.medical_specialty Angiogenesis cervical cancer medicine.medical_treatment Basic fibroblast growth factor Uterine Cervical Neoplasms Receptors Cell Surface Disease-Free Survival Neovascularization Transforming Growth Factor beta1 chemistry.chemical_compound angiogenesis Antigens CD mental disorders Plasminogen Activator Inhibitor 1 medicine Humans Molecular Diagnostics Aged Neovascularization Pathologic business.industry Macrophages Carcinoma Endoglin Middle Aged cytokines Fibronectins Gene Expression Regulation Neoplastic Platelet Endothelial Cell Adhesion Molecule-1 Vascular endothelial growth factor A Cytokine Oncology chemistry Cancer cell Cancer research cardiovascular system Blood Vessels Female Fibroblast Growth Factor 2 medicine.symptom business psychological phenomena and processes Transforming growth factor |
| Zdroj: | British Journal of Cancer British journal of cancer, 100(10), 1617-1626. Nature Publishing Group |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | In this study, we have investigated the role of endoglin (CD105), a regulator of transforming growth factor (TGF)-beta(1) signalling on endothelial cells, basic fibroblast growth factor (bFGF) and vascular endothelial growth factor-A (VEGF-A) in cervical cancer. We have measured the number and determined the location of both newly formed (CD105-positive) and the overall number of (CD31-positive) blood vessels, and bFGF and VEGF-A expression using immunohistochemistry in 30 cervical carcinoma specimens. Vascular endothelial growth factor-A mRNA expression was determined using RNA-in situ hybridisation. CD105- and CD31-positive vessels and bFGF- and VEGF-A-positive cells were predominantly present in the stroma. The presence of CD105- and CD31-positive vessels in the stroma did neither correlate with the number of VEGF-A-positive cells nor the number of bFGF-positive cells. However, the number of CD105- and CD31-positive vessels was associated with the expression of VEGF-A mRNA in the epithelial cell clusters (P=0.013 and P=0.005, respectively). The presence of CD105-positive and CD31-positive vessels was associated with the expression of alphavbeta6 (a TGF-beta(1) activator; P=0.013 and P=0.006, respectively). Clinically, the number of CD105-positive vessels associated with the number of lymph node metastasis (P |
| Databáze: | OpenAIRE |
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