Ameliorative effects of curcumin and caffeic acid against short term exposure of waterpipe tobacco smoking on lung, heart and kidney in mice
| Autor: | Darwish H. Badran, Ziad A. Shraideh, Mohammad Farajallah, Ali Ahmad Abu Siyam, Ahmed A Alzbeede, Alia Khwaldeh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Histology Histopathology Renal function Inflammation Pharmacology Antioxidants Proinflammatory cytokine Biochemical parameters 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Caffeic acid Medicine Proinflammatory cytokines 0303 health sciences Kidney Lung Disease-Oriented Research business.industry Cell Biology medicine.anatomical_structure 030301 anatomy & morphology chemistry Hookah Curcumin Original Article Anatomy medicine.symptom business 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Anatomy & Cell Biology |
| ISSN: | 2093-3673 2093-3665 |
| Popis: | This study aims to evaluate the chemopreventive activity of two antioxidants (curcumin [CUM] and caffeic acid [CAF]), focusing on how these antioxidants could reduce cytotoxicity induced by short term secondhand exposure of waterpipe tobacco smoking. Forty-eight adult male BALB/c albino mice were equally divided into four groups. Antioxidants were delivered intraperitoneally, and the exposure to waterpipe smoking (WPS) was performed using a smoking machine. This experiment lasts for 14 consecutive days. Serum were collected from mice before dissection to quantify the activity of some liver enzymes, kidney function tests and proinflammatory cytokines. Lung, heart, and kidney were isolated and processed for light microscopy technique. Parallel treatment of CUM or CAF along with exposure to WPS showed less inflammation, less vacuolized, and more inflated alveoli, less deteriorations in cortex part of kidney, and less disintegration of cardiac myofibers in comparison to waterpipe only. Besides, CUM and CAF significantly reduced the activity of aspartate aminotransferase and proinflammatory cytokines. CUM and CAF were found to have anti-inflammatory and ameliorative effects against the cytotoxicity induced by exposure to waterpipe tobacco smoking, and CUM showed better chemopreventive activity than CAF. |
| Databáze: | OpenAIRE |
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