New Biofunctional Loading of Natural Antimicrobial Agent in Biodegradable Polymeric Films for Biomedical Applications
| Autor: | Muhammad Faraz Bhatti, Fatima Darakhshan, Hafsah Akhtar, Mariam Mir, Umar Ansari, Bakhtawar Ghafoor, Murtaza Najabat Ali |
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| Rok vydání: | 2016 |
| Předmět: |
Article Subject
lcsh:Biotechnology Biomedical Engineering Aspergillus flavus 02 engineering and technology engineering.material 010402 general chemistry 01 natural sciences Polyvinyl alcohol Aloe vera Microbiology Biomaterials chemistry.chemical_compound Coating hemic and lymphatic diseases lcsh:TP248.13-248.65 In vitro degradation Food science integumentary system biology Chemistry 021001 nanoscience & nanotechnology Antimicrobial biology.organism_classification Biocompatible material Biodegradable polymer 0104 chemical sciences engineering 0210 nano-technology Research Article |
| Zdroj: | International Journal of Biomaterials, Vol 2016 (2016) International Journal of Biomaterials |
| ISSN: | 1687-8795 1687-8787 |
| DOI: | 10.1155/2016/6964938 |
| Popis: | The study focuses on the development of novelAloe verabased polymeric composite films and antimicrobial suture coatings. Polyvinyl alcohol (PVA), a synthetic biocompatible and biodegradable polymer, was combined withAloe vera, a natural herb used for soothing burning effects and cosmetic purposes. The properties of these two materials were combined together to get additional benefits such as wound healing and prevention of surgical site infections. PVA andAloe verawere mixed in a fixed quantity to produce polymer based films. The films were screened for antibacterial and antifungal activity against bacterial (E. coli,P. aeruginosa) and fungal strains (Aspergillus flavusandAspergillus tubingensis) screened.Aloe verabased PVA films showed antimicrobial activity against all the strains; the lowestAloe veraconcentration (5%) showed the highest activity against all the strains.In vitrodegradation and release profile of these films was also evaluated. The coating for sutures was prepared,in vitroantibacterial tests of these coated sutures were carried out, and later onin vivostudies of these coated sutures were also performed. The results showed that sutures coated withAloe vera/PVA coating solution have antibacterial effects and thus have the potential to be used in the prevention of surgical site infections andAloe vera/PVA based films have the potential to be used for wound healing purposes. |
| Databáze: | OpenAIRE |
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