Body pinch induces long lasting cataleptic like immobility in mice: Behavioral characterization and the effect of naloxone
| Autor: | Kurt Ornstein, Shimon Amir, Z.W. Brown, Zalman Amit |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Autonomic function Long lasting Catalepsy Behavior Animal Naloxone business.industry Movement General Medicine (+)-Naloxone medicine.disease General Biochemistry Genetics and Molecular Biology Mice Physical Stimulation Anesthesia medicine Animals Humans General Pharmacology Toxicology and Pharmaceutics business Neuroscience |
| Zdroj: | Life Sciences. 28:1189-1194 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(81)90697-4 |
| Popis: | The present article reports that repeated exposure to brief pinches at the scruff in mice results in the development of long lasting cataleptic-like immobility. The response is robust, readily induced and involves changes in autonomic functions and pain sensitivity. The development of catalepsy and the concominant antinociception are blocked by naloxone pretreatment. In contrast, naloxone fails to suppress the pinch-induced catalepsy when administered after this behavior has already been established. Taken together, the findings offer a simple and most reliable model to study the neural mechanisms that mediate “naturally occurring”, stress- induced catalepsy. |
| Databáze: | OpenAIRE |
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