Discovery of a natural thiamine adenine nucleotide
| Autor: | Marjorie Gangolf, Pierre Wins, Barbara Wirtzfeld, Tiziana Gigliobianco, Lucien Bettendorff, Michel Frederich, Luc Angenot, Edwin De Pauw, Gabriel Mazzucchelli, Alexander F Makarchikov |
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| Rok vydání: | 2006 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization biology Adenine phosphoribosyltransferase Molecular Conformation Adenosine thiamine triphosphate Cell Biology Thiamine Triphosphate Cofactor Yeast chemistry.chemical_compound Adenosine Triphosphate chemistry Biochemistry Adenine nucleotide Tandem Mass Spectrometry biology.protein Escherichia coli Thiamine Molecular Biology Thiamine triphosphate DNA Chromatography High Pressure Liquid |
| Zdroj: | Nature chemical biology. 3(4) |
| ISSN: | 1552-4450 |
| Popis: | Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues. |
| Databáze: | OpenAIRE |
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