Supplementation of beef extract improves chemotherapy-induced fatigue and toxic effects in mice
| Autor: | Hsin-Tai Hong, Jyh-Shiun Lin, Guo-Chi Lee, Chun-Yun Wu, Chia-Chi Chen, Chien-Chao Chiu, Shao-Wen Hung, Chean-Ping Wu, Tsung-Hsien Hsu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) 03 medical and health sciences Grip strength chemistry.chemical_compound 0404 agricultural biotechnology Chemotherapy induced Internal medicine Medicine Chemotherapy TX341-641 Beef extract Organ weight Fatigue chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics biology Glycogen business.industry Nutrition. Foods and food supply Glutathione peroxidase 04 agricultural and veterinary sciences 040401 food science Endocrinology chemistry Catalase biology.protein Antioxidant enzymes business Food Science |
| Zdroj: | Journal of Functional Foods, Vol 75, Iss, Pp 104232-(2020) |
| ISSN: | 1756-4646 |
| Popis: | Physiological fatigue and toxic effects are commonly associated with chemotherapy. Beef extract (BE) is a nutritional supplement obtained by cooking beef. The present study examined the effects of several BE concentrations on 5-fluorouracil (5-FU)-induced fatigue and toxic effects in mice. Results showed BE supplementation ameliorated 5-FU-induced body and organ weight loss. All BE + 5-FU groups demonstrated increased grip strength (135.3–163.2 g), endurance time (567.3–911.3 s), and movement distance (23623–31225 cm) when compared with the 5-FU group (97.6 g, 265.2 s, and 13916 cm). Hepatic and muscular (0.76 and 1.06 mg/g) glycogen levels were maintained in the BE-3x + 5-FU group when compared with the 5-FU group (0.44 and 0.58 mg/g). Moreover, catalase (liver and muscle) and glutathione peroxidase (liver) activities were enhanced. The serum alanine aminotransferase, aspartate aminotransferase, and histopathological changes were ameliorated in the BE-2x + 5-FU and BE-3x + 5-FU groups. BE supplementation could provide a novel strategy for managing 5-FU-induced fatigue and toxic effects. |
| Databáze: | OpenAIRE |
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